KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray. We generated KLHL41 mutant mice, which display lethal disruption...

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Bibliographic Details
Published in:eLife
Main Authors: Ramirez-Martinez, Andres, Cenik, Bercin Kutluk, Bezprozvannaya, Svetlana, Chen, Beibei, Bassel-Duby, Rhonda, Liu, Ning, Olson, Eric N
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589419/
https://ncbi.nlm.nih.gov/pubmed/28826497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26439
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