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Targeted dual pH-sensitive lipid siRNA self-assembly nanoparticles facilitate in vivo cytosolic siRNA delivery in tumor and overcome drug resistance by silencing eIF4E in breast cancer therapy
Down-regulation of oncogenes associated with multidrug resistance with RNAi has the potential to enhance the efficacy of cancer chemotherapy. Here, we have designed and developed targeted dual pH-sensitive lipid siRNA self-assembly nanoparticles RGD-PEG(HZ)-ECO/siRNA to enhance cytosolic siRNA deliv...
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| Wydane w: | Adv Healthc Mater |
|---|---|
| Główni autorzy: | , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589336/ https://ncbi.nlm.nih.gov/pubmed/27723260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201600677 |
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