Targeted dual pH-sensitive lipid siRNA self-assembly nanoparticles facilitate in vivo cytosolic siRNA delivery in tumor and overcome drug resistance by silencing eIF4E in breast cancer therapy

Down-regulation of oncogenes associated with multidrug resistance with RNAi has the potential to enhance the efficacy of cancer chemotherapy. Here, we have designed and developed targeted dual pH-sensitive lipid siRNA self-assembly nanoparticles RGD-PEG(HZ)-ECO/siRNA to enhance cytosolic siRNA deliv...

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Detalhes bibliográficos
Publicado no:Adv Healthc Mater
Main Authors: Gujrati, Maneesh, Mack, Margaret, Snyder, Dayton, Vaidya, Amita M., Malamas, Anthony, Lu, Zheng-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589336/
https://ncbi.nlm.nih.gov/pubmed/27723260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201600677
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