GSK1904529A, a potent IGF-IR inhibitor, reverses MRP1-mediated multidrug resistance

Overexpression of multidrug-resistant efflux transporters is one of the major causes of chemotherapy failure. MRP1, a 190 kDa efflux transporter, confers resistance to a wide of range of chemotherapeutic drugs. Here we study the cellular effects of GSK1904529A in reversing MRP1-mediated drug resista...

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Bibliografiske detaljer
Udgivet i:J Cell Biochem
Main Authors: Gupta, Pranav, Xie, Meina, Narayanan, Silpa, Wang, Yi-Jun, Wang, Xiu-Qi, Yuan, Timothy, Wang, Ziyue, Yang, Dong-Hua, Chen, Zhe-Sheng
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589182/
https://ncbi.nlm.nih.gov/pubmed/28266043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25975
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