Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10)

BACKGROUND: One of the major mechanisms that could produce resistance to antineoplastic drugs in cancer cells is the ATP binding cassette (ABC) transporters. The ABC transporters can significantly decrease the intracellular concentration of antineoplastic drugs by increasing their efflux, thereby lo...

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Detalhes bibliográficos
Main Authors: Shen, Tong, Kuang, Ye-Hong, Ashby, Charles R., Lei, Yu, Chen, Angel, Zhou, Ying, Chen, Xiang, Tiwari, Amit K., Hopper-Borge, Elizabeth, Ouyang, Jiangyong, Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759525/
https://ncbi.nlm.nih.gov/pubmed/19841739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007520
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