Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

BACKGROUND: In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T. cruzi infection, interferon gamma (IFNγ)(+) microglial cells surround astro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neuroinflammation
Prif Awduron: Silva, Andrea Alice, Silva, Rafael Rodrigues, Gibaldi, Daniel, Mariante, Rafael Meyer, dos Santos, Jessica Brandão, Pereira, Isabela Resende, Moreira, Otacílio Cruz, Lannes-Vieira, Joseli
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588596/
https://ncbi.nlm.nih.gov/pubmed/28877735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0952-0
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