A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination

RPA-coated single-stranded DNA (RPA–ssDNA), a nucleoprotein structure induced by DNA damage, promotes ATR activation and homologous recombination (HR). RPA is hyper-phosphorylated and ubiquitylated after DNA damage. The ubiquitylation of RPA by PRP19 and RFWD3 facilitates ATR activation and HR, but...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Dubois, Jean-Christophe, Yates, Maïlyn, Gaudreau-Lapierre, Antoine, Clément, Geneviève, Cappadocia, Laurent, Gaudreau, Luc, Zou, Lee, Maréchal, Alexandre
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587784/
https://ncbi.nlm.nih.gov/pubmed/28666352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx571
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires