Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), but are not good predictors of lung phenotype. Genome-wide association studies (GWAS) previously identified additional genomic sites associated with CF lung disease severity. One of these, at...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Stolzenburg, Lindsay R., Yang, Rui, Kerschner, Jenny L., Fossum, Sara, Xu, Matthew, Hoffmann, Andrew, Lamar, Kay-Marie, Ghosh, Sujana, Wachtel, Sarah, Leir, Shih-Hsing, Harris, Ann
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587731/
https://ncbi.nlm.nih.gov/pubmed/28549169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx482
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