Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), but are not good predictors of lung phenotype. Genome-wide association studies (GWAS) previously identified additional genomic sites associated with CF lung disease severity. One of these, at...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Stolzenburg, Lindsay R., Yang, Rui, Kerschner, Jenny L., Fossum, Sara, Xu, Matthew, Hoffmann, Andrew, Lamar, Kay-Marie, Ghosh, Sujana, Wachtel, Sarah, Leir, Shih-Hsing, Harris, Ann
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587731/
https://ncbi.nlm.nih.gov/pubmed/28549169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx482
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