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Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587609/ https://ncbi.nlm.nih.gov/pubmed/28878326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10993-9 |
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