Cryo-EM structure of the activated GLP-1 receptor in complex with G protein

Glucagon-like peptide-1 (GLP-1) is a hormone with essential roles in regulating insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated through binding to GLP-1R, a family B G protein-coupled receptor (GPCR) signaling primarily through the stimulatory G protein Gs. Family...

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Vydáno v:Nature
Hlavní autoři: Zhang, Yan, Sun, Bingfa, Feng, Dan, Hu, Hongli, Chu, Matthew, Qu, Qianhui, Tarrasch, Jeffrey T., Li, Shane, Kobilka, Tong Sun, Kobilka, Brian K., Skiniotis, Georgios
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587415/
https://ncbi.nlm.nih.gov/pubmed/28538729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22394
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