Phase-plate cryo-EM structure of a class B GPCR-G protein complex

Class B G protein-coupled receptors are major targets for treatment of chronic diseases, including osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Gαβγs protein determined b...

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Pubblicato in:Nature
Autori principali: Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M, Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K, Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832441/
https://ncbi.nlm.nih.gov/pubmed/28437792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22327
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