Wnt/β-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor

Gastrointestinal stromal tumor (GIST) is the most common type of sarcoma and usually harbors either a KIT or PDGFRA mutation. However, the molecular basis for tumor malignancy is not well defined. While the Wnt/β-catenin signaling pathway is important in a variety of cancers, its role in GIST is unc...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Zeng, Shan, Seifert, Adrian M., Zhang, Jennifer Q., Cavnar, Michael J., Kim, Teresa S., Balachandran, Vinod P., Santamaria-Barria, Juan A., Cohen, Noah A., Beckman, Michael J., Medina, Benjamin, Rossi, Ferdinand, Crawley, Megan H., Loo, Jennifer K., Maltbaek, Joanna H., Besmer, Peter, Antonescu, Cristina R., DeMatteo, Ronald P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587376/
https://ncbi.nlm.nih.gov/pubmed/28611108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0139
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