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The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome
Abnormal accumulation of α-synuclein (αSyn) has been linked to endoplasmic-reticulum (ER) stress, defective intracellular protein/vesicle trafficking, and cytotoxicity. Targeting factors involved in ER-related protein processing and trafficking may, therefore, be a key to modulating αSyn levels and...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587320/ https://ncbi.nlm.nih.gov/pubmed/28877262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184262 |
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