Tonic LAT-HDAC7 signals sustain Nur77 and Irf4 expression to tune naïve CD4 T cells

CD4(+) T cells differentiate into T helper cell subsets in feed-forward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naïve CD4(+) T cells avoid spontaneous engagement of feed-forward mechanisms but retain a prepared state. T...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Myers, Darienne R., Lau, Tannia, Markegard, Evan, Lim, Hyung W., Kasler, Herbert, Zhu, Minghua, Barczak, Andrea, Huizar, John P., Zikherman, Julie, Erle, David J., Zhang, Weiguo, Verdin, Eric, Roose, Jeroen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587137/
https://ncbi.nlm.nih.gov/pubmed/28538176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.076
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