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Tonic LAT-HDAC7 signals sustain Nur77 and Irf4 expression to tune naïve CD4 T cells
CD4(+) T cells differentiate into T helper cell subsets in feed-forward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naïve CD4(+) T cells avoid spontaneous engagement of feed-forward mechanisms but retain a prepared state. T...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587137/ https://ncbi.nlm.nih.gov/pubmed/28538176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.076 |
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