Reck and Gpr124 are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPCR, have been implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that vascular endothelial cell (EC)-specific reduction in Reck impairs CNS angiogenesis and that EC-specific postnatal loss of Reck combined with loss...

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Udgivet i:Neuron
Main Authors: Cho, Chris, Smallwood, Philip M., Nathans, Jeremy
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586543/
https://ncbi.nlm.nih.gov/pubmed/28803732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.07.031
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