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Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development
The molecular basis of Wnt-Frizzled specificity is a central question in developmental biology. Reck, a multi-domain and multi-functional glycosylphosphatidylinositol-anchored protein, specifically enhances beta-catenin signaling by Wnt7a and Wnt7b in cooperation with the 7-transmembrane protein Gpr...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6588345/ https://ncbi.nlm.nih.gov/pubmed/31225798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47300 |
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