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Targeted Protein Degradation by Small Molecules

Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradat...

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Detalles Bibliográficos
Publicado en:Annu Rev Pharmacol Toxicol
Main Authors: Bondeson, Daniel P., Crews, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586045/
https://ncbi.nlm.nih.gov/pubmed/27732798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010715-103507
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