Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication

We investigated the thermodynamic stability of double-stranded DNAs with an oxidative DNA lesion, 2-hydroxyadenine (2-OH-Ade), in two different sequence contexts (5′-GA*C-3′ and 5′-TA*A-3′, A* represents 2-OH-Ade). When an A*–N pair (N, any nucleotide base) was located in the center of a duplex, the...

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में प्रकाशित:	Nucleic Acids Res
मुख्य लेखकों:	Kawakami, Junji, Kamiya, Hiroyuki, Yasuda, Kyohko, Fujiki, Hiroyoshi, Kasai, Hiroshi, Sugimoto, Naoki
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Oxford University Press 2001
विषय:	Article
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.16.3289
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