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Internalized TSH receptors en route to the TGN induce local G(s)-protein signaling and gene transcription

A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Godbole, Amod, Lyga, Sandra, Lohse, Martin J., Calebiro, Davide
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585343/
https://ncbi.nlm.nih.gov/pubmed/28874659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00357-2
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