Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

G-protein–coupled receptors (GPCRs) are generally thought to signal to second messengers like cyclic AMP (cAMP) from the cell surface and to become internalized upon repeated or prolonged stimulation. Once internalized, they are supposed to stop signaling to second messengers but may trigger nonclas...

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Detalhes bibliográficos
Main Authors: Calebiro, Davide, Nikolaev, Viacheslav O., Gagliani, Maria Cristina, de Filippis, Tiziana, Dees, Christian, Tacchetti, Carlo, Persani, Luca, Lohse, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718703/
https://ncbi.nlm.nih.gov/pubmed/19688034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000172
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