Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

G-protein–coupled receptors (GPCRs) are generally thought to signal to second messengers like cyclic AMP (cAMP) from the cell surface and to become internalized upon repeated or prolonged stimulation. Once internalized, they are supposed to stop signaling to second messengers but may trigger nonclas...

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Bibliografiske detaljer
Main Authors: Calebiro, Davide, Nikolaev, Viacheslav O., Gagliani, Maria Cristina, de Filippis, Tiziana, Dees, Christian, Tacchetti, Carlo, Persani, Luca, Lohse, Martin J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718703/
https://ncbi.nlm.nih.gov/pubmed/19688034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000172
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