Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baits

Ultrasensitive methods for rare allele detection are critical to leverage the full potential offered by liquid biopsies. Here, we describe a novel molecular barcoding method for the precise detection and quantification of circulating tumor DNA (ctDNA). The major benefits of our design include straig...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Alcaide, Miguel, Yu, Stephen, Davidson, Jordan, Albuquerque, Marco, Bushell, Kevin, Fornika, Daniel, Arthur, Sarah, Grande, Bruno M., McNamara, Suzan, Tertre, Mathilde Couetoux du, Batist, Gerald, Huntsman, David G., Cavallone, Luca, Aguilar, Adriana, Basik, Mark, Johnson, Nathalie A., Deyell, Rebecca J., Rassekh, S. Rod, Morin, Ryan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585219/
https://ncbi.nlm.nih.gov/pubmed/28874686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10269-2
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