Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data

Hotspot testing for activating KRAS mutations is used in precision oncology to select colorectal cancer (CRC) patients who are eligible for anti-EGFR treatment. However, even for KRAS(wildtype) tumors anti-EGFR response rates are <30%, while mutated-KRAS does not entirely rule out response, indic...

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Pubblicato in:Cancers (Basel)
Autori principali: Blank-Landeshammer, Bernhard, Richard, Vincent R., Mitsa, Georgia, Marques, Maud, LeBlanc, André, Kollipara, Laxmikanth, Feldmann, Ingo, Couetoux du Tertre, Mathilde, Gambaro, Karen, McNamara, Suzan, Spatz, Alan, Zahedi, René P., Sickmann, Albert, Batist, Gerald, Borchers, Christoph H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966481/
https://ncbi.nlm.nih.gov/pubmed/31805664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121907
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