Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data

Hotspot testing for activating KRAS mutations is used in precision oncology to select colorectal cancer (CRC) patients who are eligible for anti-EGFR treatment. However, even for KRAS(wildtype) tumors anti-EGFR response rates are <30%, while mutated-KRAS does not entirely rule out response, indic...

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Publicat a:Cancers (Basel)
Autors principals: Blank-Landeshammer, Bernhard, Richard, Vincent R., Mitsa, Georgia, Marques, Maud, LeBlanc, André, Kollipara, Laxmikanth, Feldmann, Ingo, Couetoux du Tertre, Mathilde, Gambaro, Karen, McNamara, Suzan, Spatz, Alan, Zahedi, René P., Sickmann, Albert, Batist, Gerald, Borchers, Christoph H.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966481/
https://ncbi.nlm.nih.gov/pubmed/31805664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121907
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