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Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment

Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and cellular tumor microenvironment which suppresses adoptively transferred T cells. We engineered an armo...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Yeku, Oladapo O., Purdon, Terence J., Koneru, Mythili, Spriggs, David, Brentjens, Renier J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585170/
https://ncbi.nlm.nih.gov/pubmed/28874817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10940-8
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