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Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and cellular tumor microenvironment which suppresses adoptively transferred T cells. We engineered an armo...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5585170/ https://ncbi.nlm.nih.gov/pubmed/28874817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10940-8 |
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