Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases

Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar structures, acquire aberrant (misfolded) conformations toxic to cells. To prevent misfolded protein toxicity, cells activate...

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Vydáno v:Autophagy
Hlavní autoři: Cristofani, Riccardo, Crippa, Valeria, Rusmini, Paola, Cicardi, Maria Elena, Meroni, Marco, Licata, Nausicaa V., Sala, Gessica, Giorgetti, Elisa, Grunseich, Christopher, Galbiati, Mariarita, Piccolella, Margherita, Messi, Elio, Ferrarese, Carlo, Carra, Serena, Poletti, Angelo
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Basic Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584856/
https://ncbi.nlm.nih.gov/pubmed/28402699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1308985
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