Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

Neurodegenerative diseases (NDs) are often associated with the presence of misfolded protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle structures affected during NDs progression. HSPB8 exerts a potent pro-degradative activity on several misfolded proteins res...

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izdano v:Sci Rep
Main Authors: Crippa, Valeria, D’Agostino, Vito G., Cristofani, Riccardo, Rusmini, Paola, Cicardi, Maria E., Messi, Elio, Loffredo, Rosa, Pancher, Michael, Piccolella, Margherita, Galbiati, Mariarita, Meroni, Marco, Cereda, Cristina, Carra, Serena, Provenzani, Alessandro, Poletti, Angelo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785366/
https://ncbi.nlm.nih.gov/pubmed/26961006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22827
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