Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

Neurodegenerative diseases (NDs) are often associated with the presence of misfolded protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle structures affected during NDs progression. HSPB8 exerts a potent pro-degradative activity on several misfolded proteins res...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Crippa, Valeria, D’Agostino, Vito G., Cristofani, Riccardo, Rusmini, Paola, Cicardi, Maria E., Messi, Elio, Loffredo, Rosa, Pancher, Michael, Piccolella, Margherita, Galbiati, Mariarita, Meroni, Marco, Cereda, Cristina, Carra, Serena, Provenzani, Alessandro, Poletti, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785366/
https://ncbi.nlm.nih.gov/pubmed/26961006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22827
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