Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases

Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar structures, acquire aberrant (misfolded) conformations toxic to cells. To prevent misfolded protein toxicity, cells activate...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Cristofani, Riccardo, Crippa, Valeria, Rusmini, Paola, Cicardi, Maria Elena, Meroni, Marco, Licata, Nausicaa V., Sala, Gessica, Giorgetti, Elisa, Grunseich, Christopher, Galbiati, Mariarita, Piccolella, Margherita, Messi, Elio, Ferrarese, Carlo, Carra, Serena, Poletti, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584856/
https://ncbi.nlm.nih.gov/pubmed/28402699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1308985
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