Induction of Mitochondrial Biogenesis Protects against Acetaminophen Hepatotoxicity

Mitochondrial biogenesis (MB) is an adaptive response to maintain metabolic homeostasis after mitochondrial dysfunction. Induction of MB during APAP hepatotoxicity has not been studied. To investigate this, mice were treated with toxic doses of APAP and euthanized between 0 and 96h. At early time po...

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Gepubliceerd in:Food Chem Toxicol
Hoofdauteurs: Du, Kuo, Ramachandran, Anup, McGill, Mitchell R., Mansouri, Abdellah, Asselah, Tarik, Farhood, Anwar, Woolbright, Benjamin L., Ding, Wen-Xing, Jaeschke, Hartmut
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584682/
https://ncbi.nlm.nih.gov/pubmed/28827156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2017.08.020
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