Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation

An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are among those most strongly and reproducibly associated with obesity. The gene closest to these variants is TMEM18, although the molecular mechanisms mediating these effects remain entirely unknown. Tmem18 expressio...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Larder, Rachel, Sim, M. F. Michelle, Gulati, Pawan, Antrobus, Robin, Tung, Y. C. Loraine, Rimmington, Debra, Ayuso, Eduard, Polex-Wolf, Joseph, Lam, Brian Y. H., Dias, Cristina, Logan, Darren W., Virtue, Sam, Bosch, Fatima, Yeo, Giles S. H., Saudek, Vladimir, O’Rahilly, Stephen, Coll, Anthony P.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584443/
https://ncbi.nlm.nih.gov/pubmed/28811369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707310114
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