Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation

An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are among those most strongly and reproducibly associated with obesity. The gene closest to these variants is TMEM18, although the molecular mechanisms mediating these effects remain entirely unknown. Tmem18 expressio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Larder, Rachel, Sim, M. F. Michelle, Gulati, Pawan, Antrobus, Robin, Tung, Y. C. Loraine, Rimmington, Debra, Ayuso, Eduard, Polex-Wolf, Joseph, Lam, Brian Y. H., Dias, Cristina, Logan, Darren W., Virtue, Sam, Bosch, Fatima, Yeo, Giles S. H., Saudek, Vladimir, O’Rahilly, Stephen, Coll, Anthony P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584443/
https://ncbi.nlm.nih.gov/pubmed/28811369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707310114
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