In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is a deadly cancer, and its prognosis has not been changed significantly during several decades. To seek new therapeutic targets for EOC, we performed an in vivo dropout screen in human tumor xenografts using a pooled shRNA library targeting thousands of druggable gen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kodama, Michiko, Kodama, Takahiro, Newberg, Justin Y., Katayama, Hiroyuki, Kobayashi, Makoto, Hanash, Samir M., Yoshihara, Kosuke, Wei, Zhubo, Tien, Jean C., Rangel, Roberto, Hashimoto, Kae, Mabuchi, Seiji, Sawada, Kenjiro, Kimura, Tadashi, Copeland, Neal G., Jenkins, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584430/
https://ncbi.nlm.nih.gov/pubmed/28811376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705441114
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