In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is a deadly cancer, and its prognosis has not been changed significantly during several decades. To seek new therapeutic targets for EOC, we performed an in vivo dropout screen in human tumor xenografts using a pooled shRNA library targeting thousands of druggable gen...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kodama, Michiko, Kodama, Takahiro, Newberg, Justin Y., Katayama, Hiroyuki, Kobayashi, Makoto, Hanash, Samir M., Yoshihara, Kosuke, Wei, Zhubo, Tien, Jean C., Rangel, Roberto, Hashimoto, Kae, Mabuchi, Seiji, Sawada, Kenjiro, Kimura, Tadashi, Copeland, Neal G., Jenkins, Nancy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584430/
https://ncbi.nlm.nih.gov/pubmed/28811376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705441114
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