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Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis

Mucociliary clearance is composed of three components (i.e., mucin secretion, airway surface hydration, and ciliary-activity) which function coordinately to clear inhaled microbes and other foreign particles from airway surfaces. Airway surface hydration is maintained by water fluxes driven predomin...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Sandefur, Conner I., Boucher, Richard C., Elston, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584404/
https://ncbi.nlm.nih.gov/pubmed/28808008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617383114
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