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Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease
The pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand mismatch, due to hemodynamic adaptations, with resultant hypoxia, plays an important role in the pathophysiology in early CKD....
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| Publicado no: | Am J Physiol Renal Physiol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582905/ https://ncbi.nlm.nih.gov/pubmed/28331062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00579.2016 |
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