Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease

The pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand mismatch, due to hemodynamic adaptations, with resultant hypoxia, plays an important role in the pathophysiology in early CKD....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Renal Physiol
Prif Awduron: Thomas, Joanna L., Pham, Hai, Li, Ying, Hall, Elanore, Perkins, Guy A., Ali, Sameh S., Patel, Hemal H., Singh, Prabhleen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582905/
https://ncbi.nlm.nih.gov/pubmed/28331062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00579.2016
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