Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease

The pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand mismatch, due to hemodynamic adaptations, with resultant hypoxia, plays an important role in the pathophysiology in early CKD....

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Détails bibliographiques
Publié dans:Am J Physiol Renal Physiol
Auteurs principaux: Thomas, Joanna L., Pham, Hai, Li, Ying, Hall, Elanore, Perkins, Guy A., Ali, Sameh S., Patel, Hemal H., Singh, Prabhleen
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582905/
https://ncbi.nlm.nih.gov/pubmed/28331062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00579.2016
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