Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease

The pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand mismatch, due to hemodynamic adaptations, with resultant hypoxia, plays an important role in the pathophysiology in early CKD....

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Bibliografski detalji
Izdano u:Am J Physiol Renal Physiol
Glavni autori: Thomas, Joanna L., Pham, Hai, Li, Ying, Hall, Elanore, Perkins, Guy A., Ali, Sameh S., Patel, Hemal H., Singh, Prabhleen
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582905/
https://ncbi.nlm.nih.gov/pubmed/28331062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00579.2016
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