Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease

The pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand mismatch, due to hemodynamic adaptations, with resultant hypoxia, plays an important role in the pathophysiology in early CKD....

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Thomas, Joanna L., Pham, Hai, Li, Ying, Hall, Elanore, Perkins, Guy A., Ali, Sameh S., Patel, Hemal H., Singh, Prabhleen
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582905/
https://ncbi.nlm.nih.gov/pubmed/28331062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00579.2016
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