Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. mGluRs can form both constitutive ho...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Liu, Junke, Zhang, Zongyong, Moreno-Delgado, David, Dalton, James AR, Rovira, Xavier, Trapero, Ana, Goudet, Cyril, Llebaria, Amadeu, Giraldo, Jesús, Yuan, Qilin, Rondard, Philippe, Huang, Siluo, Liu, Jianfeng, Pin, Jean-Philippe
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582870/
https://ncbi.nlm.nih.gov/pubmed/28829739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26985
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