Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. mGluRs can form both constitutive ho...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Liu, Junke, Zhang, Zongyong, Moreno-Delgado, David, Dalton, James AR, Rovira, Xavier, Trapero, Ana, Goudet, Cyril, Llebaria, Amadeu, Giraldo, Jesús, Yuan, Qilin, Rondard, Philippe, Huang, Siluo, Liu, Jianfeng, Pin, Jean-Philippe
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582870/
https://ncbi.nlm.nih.gov/pubmed/28829739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26985
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