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Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

The interaction of the intrinsically disordered polypeptide islet amyloid polypeptide (IAPP), which is associated with type 2 diabetes (T2D), with the Alzheimer's disease amyloid-β (Aβ) peptide modulates their self-assembly into amyloid fibrils and may link the pathogeneses of these two cell-de...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Bakou, Maria, Hille, Kathleen, Kracklauer, Michael, Spanopoulou, Anna, Frost, Christina V., Malideli, Eleni, Yan, Li-Mei, Caporale, Andrea, Zacharias, Martin, Kapurniotu, Aphrodite
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582850/
https://ncbi.nlm.nih.gov/pubmed/28684415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.774893
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