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Computational tools help improve protein stability but with a solubility tradeoff

Accurately predicting changes in protein stability upon amino acid substitution is a much sought after goal. Destabilizing mutations are often implicated in disease, whereas stabilizing mutations are of great value for industrial and therapeutic biotechnology. Increasing protein stability is an espe...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Broom, Aron, Jacobi, Zachary, Trainor, Kyle, Meiering, Elizabeth M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582830/
https://ncbi.nlm.nih.gov/pubmed/28710274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784165
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