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Conformational flexibility of histone variant CENP-A(Cse4) is regulated by histone H4: A mechanism to stabilize soluble Cse4
The histone variant CENP-A(Cse4) is a core component of the specialized nucleosome at the centromere in budding yeast and is required for genomic integrity. Accordingly, the levels of Cse4 in cells are tightly regulated, primarily by ubiquitin-mediated proteolysis. However, structural transitions in...
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| Gepubliceerd in: | J Biol Chem |
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| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6311523/ https://ncbi.nlm.nih.gov/pubmed/30381395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004141 |
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