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Tenapanor administration and the activity of the H(+)‐coupled transporter PepT1 in healthy volunteers

AIM: Tenapanor (RDX5791/AZD1722), an inhibitor of gastrointestinal Na(+)/H(+) exchanger NHE3, is being evaluated for the treatment of patients with constipation‐predominant irritable bowel syndrome and the treatment of hyperphosphataemia in patients with chronic kidney disease on dialysis. By reduci...

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Détails bibliographiques
Publié dans:Br J Clin Pharmacol
Auteurs principaux: Johansson, Susanne, Rosenbaum, David P., Palm, Johan, Stefansson, Bergur, Knutsson, Mikael, Lisbon, Eleanor A., Hilgendorf, Constanze
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582369/
https://ncbi.nlm.nih.gov/pubmed/28432691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13313
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