Preclinical and Healthy Volunteer Studies of Potential Drug–Drug Interactions Between Tenapanor and Phosphate Binders

Tenapanor (RDX5791, AZD1722), a first‐in‐class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption of sodium and phosphate. It is being studied in patients with chronic kidney di...

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Foilsithe in:Clin Pharmacol Drug Dev
Main Authors: Johansson, Susanne, Leonsson‐Zachrisson, Maria, Knutsson, Mikael, Spencer, Andrew G., Labonté, Eric D., Deshpande, Desiree, Kohler, Jill, Kozuka, Kenji, Charmot, Dominique, Rosenbaum, David P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2016
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599948/
https://ncbi.nlm.nih.gov/pubmed/27654985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.307
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