Altered Developmental Expression of the Astrocyte-Secreted Factors Hevin and SPARC in the Fragile X Mouse Model

Astrocyte dysfunction has been indicated in many neurodevelopmental disorders, including Fragile X Syndrome (FXS). FXS is caused by a deficiency in fragile X mental retardation protein (FMRP). FMRP regulates the translation of numerous mRNAs and its loss disturbs the composition of proteins importan...

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Udgivet i:Front Mol Neurosci
Main Authors: Wallingford, Jessica, Scott, Angela L., Rodrigues, Kelly, Doering, Laurie C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581809/
https://ncbi.nlm.nih.gov/pubmed/28900386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00268
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