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Cytosine deaminase APOBEC3A sensitizes leukemia cells to inhibition of the DNA replication checkpoint

Mutational signatures in cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeutic vulnerability. Elevated APOBEC3B expression has been detected in solid tumors, but expression of APOBEC3A (A3A) in cancer has not been described to date. Here we re...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Green, Abby M., Budagyan, Konstantin, Hayer, Katharina E., Reed, Morgann A., Savani, Milan R., Wertheim, Gerald B., Weitzman, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581702/
https://ncbi.nlm.nih.gov/pubmed/28655787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3394
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