Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury

OBJECTIVE: To explore the effects of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain (CNP) and spinal microglia in a rat model of chronic constriction injury (CCI). METHODS: Male SD rats were assigned into control, sham, CCI, wortmannin, dimethyl sulfoxide (DMSO) and wortmanni...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Guo, Jian-Rong, Wang, Huan, Jin, Xiao-Ju, Jia, Dong-Lin, Zhou, Xun, Tao, Qiang
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581082/
https://ncbi.nlm.nih.gov/pubmed/28881783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17629
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